The story is set in December of 2199, when the streets are full of anticipation for the end of the year and the start of the new one. Amid the celebrations, word spreads that Ragna the Bloodedge, an SS-class rebel with the highest ever bounty on his head, has appeared in the 13th Hierarchical City of Kagutsuchi. The apparent aim of Ragna or the "Grim Reaper" is the destruction of the system controlling the world. To collect the bounty, a motley array of unrivaled fighters converge on Kagutsuchi. (Source: Anime News Network)
Jin Kisaragi
Ragna the Bloodedge
Noel Vermillion
Hazama
Rachel Alucard
Litchi Faye-Ling
Taokaka
Carl Clover
Bang Shishigami
Kokonoe
Tsubaki Yayoi
Hakumen
Makoto Nanaya
Arakune
Nu-13
Lambda-11
Iron Tager
Trinity Glassfille
Mitsuyoshi
Valkenhayn Hellsing
After dying in another time-line, Ragna the Bloodedge seeks to continue his quest. He fights with his brother, Jin Kisaragi, and meets Noel Vermillion, who has strange memories of him.
Ragna beats Hakumen, one of the Six Heroes, and is next faced with Nu-13. Noel, the true successor to the Azure, saves his life and kills Nu.
Rachel has her showdown with Takemikazuchi, Hazama shows his true colors, and Ragna faces a fight with yet another bounty hunter.
As Ragna recovers from his wounds, Rachel meets with three mysterious beings and Noel runs into an old friend and classmate from the Military Academy.
Rachel conducts her own mysterious business as usual, porting from place to place. Kokonoe has her own agenda and sends Tager to carry out a mission. And Ragna works towards a full recovery with the help of some friends.
Kokonoe's little gambit with Ragna plays out. In the meantime, Jin is still searching for Ragna, but instead, ends up being found by Bang Shishigami, who wants revenge against Jin.
Tager continues to slowly track Noel. Noel finds Tsubaki, which results in a complicated showdown. And Rachel leads Ragna to where he needs to be and to confront what he already knows.
Hazama throws an obstacle in Ragna's way to buy himself some time. This encounter leads Ragna to have an entirely different sort of experience with Lambda.
As Makoto works to get Noel to safety, she explains her faith in Kokonoe and her doubts about Hazama. And Tsubaki finally finds Jin again, who is still struggling to deal with his recalcitrant weapon.
Noel and Makoto fight a losing battle against Hazama while Ragna fights Jin inside the Cathedral. Noel disappears, and Hazama reveals a secret to Ragna.
Hazama's interference keeps Ragna from using his powers. Noel is reborn in the Cauldron as Mu-12 and attacks her former friends.
Kokonoe and Rachel believe that Noel's transformation into Mu is irreversible, but Ragna refuses to give up on Noel.